Temozolomide
| Code | Size | Price |
|---|
| CDX-T0072-M250 | 250 mg | £364.00 |
Quantity:
| CDX-T0072-G001 | 1 g | £926.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; CCRG 81045; MB 39831; Methazolastone; NSC 362856; Temodal
Appearance:
White to light pink powder.
CAS:
85622-93-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H315-H319-H335-H350-H360
InChi:
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChiKey:
BPEGJWRSRHCHSN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 85622-93-1. Formula: C6H6N6O2. MW: 194.15. Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.
MDL:
MFCD00866492
Molecular Formula:
C6H6N6O2
Molecular Weight:
194.15
Package Type:
Vial
Precautions:
P201-P261-P305 + P351 + P338-P308 + P313
Product Description:
Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
O=C1N(C)N=NC2=C(C(N)=O)N=CN21
Solubility Chemicals:
Soluble in DMSO (5mg/ml) or DMF (5mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) A.S. Clark, et al.; J. Med. Chem. 38, 1493 (1995) | (2) E.S. Newlands, et al.; Cancer Treat. Rev. 23, 35 (1997) (Review) | (3) S.S. Agarwala & J.M. Kirkwood; Oncologist 5, 144 (2000) (Review) | (4) S.J. Danson & M.R. Middleton; Expert Rev. Anticancer Ther. 1, 13 (2001) (Review) | (5) T. Kanzawa, et al.; Cell Death Differ. 11, 448 (2004) | (6) F. Marchesi, et al.; Pharmacol. Res. 56, 275 (2007) | (7) G. Jiang, et al.; Curr. Med. Chem. 19, 3886 (2012) (Review)