Procyclidine hydrochloride
| Code | Size | Price |
|---|
| CDX-P0608-G001 | 1 g | £121.00 |
Quantity:
| CDX-P0608-G005 | 5 g | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
alpha-Cyclohexyl-alpha-phenyl-1-pyrrolidinepropanol; Arpicolin; Tricyclamol hydrochloride
Appearance:
White to off-white powder.
CAS:
1508-76-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H312-H319-H332-H335
InChi:
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
InChiKey:
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1508-76-5. Formula: C19H29NO . HCl. MW: 323.9. Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson?s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
MDL:
MFCD00079236
Molecular Formula:
C19H29NO . HCl
Molecular Weight:
323.9
Package Type:
Vial
Product Description:
Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson?s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
Purity:
>98% (TLC)
SMILES:
OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl
Solubility Chemicals:
Soluble in DMOS, DMF, ethanol (all 1mg/ml) or chloroform.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) R.B. Barlow, et al.; Br. J. Pharmacol. 72, 277 (1981) | (2) M. Waelbroeck, et al.; Eur. J. Pharmacol. 189, 135 (1990) | (3) S. Lazareno, et al.; Mol. Pharmacol. 38, 805 (1990) | (4) T. Zarnowski, et al.; J. Neural. Transm. Gen. Sect. 97, 1 (1994) | (5) M.L. Sipos, et al.; Psychopharmacol. 147, 250 (1999) | (6) V. Jevtovic-Todorovic, et al.; Neuropharmacol. 44, 739 (2003) | (7) R. Roesler, et al.; J. Clin. Psychopharmacol. 23, 666 (2003)