Bimatoprost
| Code | Size | Price |
|---|
| CDX-P0325-M001 | 1 mg | £102.00 |
Quantity:
| CDX-P0325-M005 | 5 mg | £371.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
17-Phenyl-tri-norprostaglandin F2alpha-ethyl amide; cGMP Bimatoprost; AGN-192024; Lumigan; Prostamide
Appearance:
White powder.
CAS:
155206-00-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
InChiKey:
AQOKCDNYWBIDND-FTOWTWDKSA-N
Long Description:
Chemical. CAS: 155206-00-1. Formula: C25H37NO4. MW: 415.57. Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2alpha that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2alpha, a potent PGF2alphaR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
MDL:
MFCD03411999
Molecular Formula:
C25H37NO4
Molecular Weight:
415.57
Package Type:
Vial
Product Description:
Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2alpha that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2alpha, a potent PGF2alphaR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
Purity:
>95% (HPLC)
SMILES:
O[C@H]1C[C@@H](O)[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H]1C/C=CCCCC(NCC)=O
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) L.B. Cantor, et al.; Expert Opin. Investig. Drugs 10, 721 (2001) (Review) | (2) R.F. Brubaker; Surv. Ophthalmol. 45, S347 (2001) (Review) | (3) A.H. Krauss & D.F. Woodward; Surv. Ophthalmol. 49, S5 (2004) (Review) | (4) D.F. Woodward, et al.; Cardiovasc. Drug Rev. 22, 103 (2004) (Review)