Sancycline
| Code | Size | Price |
|---|
| CDX-S0344-M250 | 250 mg | £175.00 |
Quantity:
| CDX-S0344-G001 | 1 g | £499.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
6-Demethyl-6-deoxytetracycline; Bonomycin; Norcycline; GS 2147
Appearance:
Yellow to green powder.
CAS:
808-26-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24,26-27,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1
InChiKey:
XDVCLKFLRAWGIT-ADOAZJKMSA-N
Long Description:
Chemical. CAS: 808-26-4. Formula: C21H22N2O7. MW: 414.4. Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 µg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 µg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
MDL:
MFCD00864992
Molecular Formula:
C21H22N2O7
Molecular Weight:
414.4
Package Type:
Vial
Precautions:
P201, P260, P263, P264, P270, P330, P301+P310, P308+P313, P501
Product Description:
Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 µg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 µg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC1=C2C(C[C@]3([H])C(C2=O)=C(O)[C@@]4(O)[C@@]([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)([H])C3)=CC=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) J.R.D. McCormick, et al.; JACS 82, 3381 (1960) | (2) R.T. Testa, et al.; Antimicrob. Agents Chemother. 37, 2270 (1993) | (3) H.M. Wexler, et al.; Antimicrob. Agents Chemother. 38, 2513 (1994)