Nadolol
| Code | Size | Price |
|---|
| CDX-N0141-G001 | 1 g | £65.00 |
Quantity:
| CDX-N0141-G005 | 5 g | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Corgard; SQ11725
Appearance:
White to off-white powder.
CAS:
42200-33-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1
InChiKey:
VWPOSFSPZNDTMJ-UCWKZMIHSA-N
Long Description:
Chemical. CAS: 42200-33-9. Formula: C17H27NO4. MW: 309.4. Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol's inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
MDL:
MFCD00079476
Molecular Formula:
C17H27NO4
Molecular Weight:
309.4
Package Type:
Vial
Product Description:
Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol's inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
Purity:
>98% (GC)
SMILES:
O[C@H]1[C@@H](O)CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2C1
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or DMF.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) D.B. Evans, et al.; Eur. J. Pharmacol. 35, 17 (1976) | (2) W. Frishman; Am. Heart J. 99, 124 (1980) (Review) | (3) R.C. Heel, et al.; Drugs 20, 1 (1980) (Review) | (4) W.H. Frishman; N. Engl. J. Med. 305, 678 (1981) (Review) | (5) H. Peng, et al.; 383, 209 (2011)