Hyodeoxycholic acid
| Code | Size | Price |
|---|
| CDX-H0198-G010 | 10 g | £108.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
HDCA; 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid; NSC 60672; BRN 3218394; Iodeoxycholic acid
Appearance:
White powder.
CAS:
83-49-8
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChiKey:
DGABKXLVXPYZII-SIBKNCMHSA-N
Long Description:
Chemical. CAS: 83-49-8. Formula: C24H40O4. MW: 392.57. Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn?s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/precursor for steroid synthesis.
MDL:
MFCD00003681
Molecular Formula:
C24H40O4
Molecular Weight:
392.57
Package Type:
Vial
Product Description:
Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn?s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/precursor for steroid synthesis.
Purity:
>98% (HPLC)
SMILES:
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])C1
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (30mg/ml) or ethanol (20mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) W.Z. Chow & D.C. Huang; Sci. Sin. 14, 1083 (1965) | (2) K. Einarsson; J. Biol. Chem. 241, 534 (1966) | (3) K. Ochi, et al.; Steroids 30, 795 (1977) | (4) K.R. Bharucha; Steroids 32, 589 (1978) | (5) C.K. McSherry, et al.; Am. J. Surg. 149, 126 (1985) | (6) E. Sehayek, et al.; J. Lipid Res. 42, 1250 (2001) | (7) C. Gnewuch, et al.; World J. Gastroenterol. 15, 3134 (2009) | (8) D.M. Shih, et al.; FASEB J. 27, 3805 (2013) | (9) S. Watanabe & K. Fujita; Lipids 49, 963 (2014)