Mildronate dihydrate
| Code | Size | Price |
|---|
| CDX-M0558-M010 | 10 mg | £41.00 |
Quantity:
| CDX-M0558-M025 | 25 mg | £78.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Meldonium; MET 88; Quaterin; THP
Appearance:
White to off-white powder.
CAS:
86426-17-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
InChiKey:
PVBQYTCFVWZSJK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 86426-17-7. Formula: C6H14N2O2 . 2H2O. MW: 182.22. Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimer?s disease.
MDL:
MFCD00876389
Molecular Formula:
C6H14N2O2 . 2H2O
Molecular Weight:
182.22
Package Type:
Vial
Precautions:
P261-P305 + P351 + P338
Product Description:
Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimer?s disease.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
[O-]C(CCN[N+](C)(C)C)=O
Solubility Chemicals:
Soluble in water (20mg/ml) or ethanol (20mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) B.Z. Simkhovich, et al.; Biochem. Pharmacol. 37, 195 (1988) | (2) M. Dambrova, et al.; Trends Cardiovasc. Med. 12, 275 (2002) (Review) | (3) E. Liepinsh, et al.; J. Cardiovasc. Pharmacol. 48, 314 (2006) | (4) R. Vilskersts, et al.; Pharmacology 83, 287 (2009) | (5) K. Jaudzems, et al.; J. Enzyme Inhib. Med. Chem. 24, 1269 (2009) | (6) J. Pupure, et al.; Neurosci. Lett. 470, 100 (2010) | (7) V.Z. Klusa, et al.; Int. J. Mol. Sci. 11, 4465 (2010) | (8) I.K. Leung, et al.; Chem. Biol. 17, 1316 (2010) | (9) E. Liepinsh, et al.; Eur. J. Pharmacol. 658, 277 (2011) | (10) K. Tars, et al.; J. Med. Chem. 57, 2213 (2014) | (11) U. Beitnere, et al.; J. Neurosci. Res. 92, 338 (2014) | (12) M. Makrecka, et al.; Eur. J. Pharmacol. 723, 55 (2014)