USP2 Antibody
Code | Size | Price |
---|
NSJ-F53953-0.05ML | 0.05 ml | £260.00 |
Quantity:
NSJ-F53953-0.2ML | 0.2 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 1738CT331.50.87
Regulatory Status: RUO
Target Species:
- African Green Monkey (sabaeus)
- Human
Application: Western Blot (WB)
Storage:
Aliquot the USP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Further Information
Application Details :
Western blot: 1:1000-2000
Description:
Ubiquitin carboxyl-terminal hydrolase 2 is a hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Gene ID #:
9099
Immunogen:
A partial recombinant protein corresponding to amino acids 1-258 from the human protein was used as the immunogen for the USP2 antibody.
Limitation:
This USP2 antibody is available for research use only.
Purity:
Protein G affinity chromatography
Species Reactivity :
Human, African Green Monkey
Uniprot #:
O75604