TGFB2 Antibody

IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Western blot: 1:100-1:1000

Titration of the TGFB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

This TGFB2 antibody was produced from a mouse immunized with TGFB2 recombinant protein.

This TGFB2 antibody is available for research use only.

Purified

Human

P61812