Desmin Antibody (Muscle cell marker)

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Optimal dilution of the Desmin antibody should be determined by the researcher.

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain a-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Bioreactor concentrate

Bioreactor concentrate with 0.05% sodium azide

Human leiomyoma proteins were used as the immunogen for the Desmin antibody.

This Desmin antibody is available for research use only.

Cytoplasmic, membranous

Unpurified high titer supernatant

Human, Rat

P17661