CD105 Antibody / Endoglin

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NSJ Bioreagents
Product Code: NSJ-V8568
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V8568-20UG20 ug£264.00
Quantity:
NSJ-V8568-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: ENG/1621
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Fluorescence-activated cell sorting (FACS)
  • Immunofluorescence (IF)
Storage:
Store the Endoglin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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Flow cytometry testing of PFA-fixed human HeLa cells with Endoglin antibody (clone ENG/1621); Red=isotype control, Blue= Endoglin antibody.
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Immunofluorescent staining of PFA-fixed human HeLa cells with Endoglin antibody (clone ENG/1621).
3 / 3
SDS-PAGE analysis of purified, BSA-free Endoglin antibody (clone ENG/1621) as confirmation of integrity and purity.
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Flow cytometry testing of PFA-fixed human HeLa cells with Endoglin antibody (clone ENG/1621); Red=isotype control, Blue= Endoglin antibody.
Immunofluorescent staining of PFA-fixed human HeLa cells with Endoglin antibody (clone ENG/1621).
SDS-PAGE analysis of purified, BSA-free Endoglin antibody (clone ENG/1621) as confirmation of integrity and purity.

Documents

Further Information

Application Details :
ELISA: order Ab without BSA for coating,Flow cytometry: 1-2ug/million cells,Immunofluorescence: 2-4ug/ml
Application Note:
Optimal dilution of the Endoglin antibody should be determined by the researcher.
Description:
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant extracellular fragment from the human protein was used as the immunogen for the Endoglin antibody.
Limitation:
This Endoglin antibody is available for research use only.
Localization:
Cell surface
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
P17813