hCG Receptor / LH Receptor Antibody

Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml

Optimal dilution of the hCG Receptor antibody should be determined by the researcher.

Recognizes a protein of 78-85kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the hCG Receptor antibody.

This hCG Receptor antibody is available for research use only.

Cytoplasmic, cell surface

Protein G affinity chromatography

Human

P22888