IGF-1 Antibody / Insulin like Growth Factor 1

Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 1-2ug/ml,In-vitro neutralization of biological activity of IGF-1 (order BSA/sodium azide-free format)

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

This antibody is specific to IGF1 (Insulin like Growth Factor 1) and shows minimal cross-reaction with IGF11, Proinsulin, MSF, and Insulin. IGF1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF1B while isoform 2 is known as IGF1A. IGF1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of the IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

3479

Purified human IGF1 protein was used as the immunogen for this antibody.

This IGF1 antibody is available for research use only.

Cytoplasmic (Secreted)

Protein G affinity chromatography

Human, Mouse, Rat