Neuregulin-1 Antibody / NRG1

ELISA (order BSA/sodium azide-free format for coating),Immunofluorescence: 1-2ug/ml

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Neuregulin-1 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Heregulin-1 / Neuregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

A portion of amino acids 21-242 from the human protein was used as the immunogen for this Neuregulin-1 antibody.

This Neuregulin-1 antibody is available for research use only.

Cytoplasmic, plasma membrane, nuclear

Yes

Protein G affinity chromatography

Human

Q02297