Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)

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NSJ Bioreagents
Product Code: NSJ-V3432
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V3432-20UG20 ug£264.00
Quantity:
NSJ-V3432-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: SPM222
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Store the TSH Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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IHC testing of FFPE human thyroid carcinoma with TSH Receptor antibody (clone SPM222). Required HIER: boil tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8, for 10-20 min followed by cooling at RT for 20 min.
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IHC testing of FFPE human thyroid carcinoma with TSH Receptor antibody (clone SPM222). Required HIER: boil tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8, for 10-20 min followed by cooling at RT for 20 min.

Documents

Further Information

Application Details :
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Application Note:
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSH Receptor antibody to be titered up or down for optimal performance.
Description:
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Immunogen:
Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.
Limitation:
This TSH Receptor antibody is available for research use only.
Localization:
Cytoplasmic, cell surface
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
P16473