TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1

ELISA (order BSA-free format for coating)

Optimal dilution of the antibody should be determined by the researcher.

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.

Purified

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.

This TAL1 antibody is available for research use only.

Protein G affinity chromatography

Human

P17542