Integrin beta 4 Antibody / ITGB4 / CD104
Code | Size | Price |
---|
NSJ-V2163-20UG | 20 ug | £264.00 |
Quantity:
NSJ-V2163-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: UM-A9
Regulatory Status: RUO
Target Species: Human
Applications:
- Blocking
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
Storage:
Store the Integrin Beta 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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Further Information
Application Details :
Biological Blockade (Partially blocks laminin binding) (order BSA/sodium azide-free format),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml
Application Note:
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
Description:
This antibody recognizes a protein of 205kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of a and b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of a and b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Gene ID #:
3691
Immunogen:
The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta 4 / CD104 antibody.
Limitation:
This Integrin Beta 4 antibody is available for research use only.
Localization:
Cell surface
Purity:
Protein G affinity chromatography
Species Reactivity :
Human