von Willebrand Factor Antibody / vWF
| Code | Size | Price |
|---|
| NSJ-V7082-20UG | 20 ug | £264.00 |
Quantity:
| NSJ-V7082-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: WFA52-2
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Store the von Willebrand Factor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Documents
Further Information
Application Details :
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Application Note:
Variations in protocols, secondaries and substrates may require the von Willebrand Factor antibody to be titered for optimal performance.
Description:
von Willebrand Factor (vWF) is a glycoprotein produced by bone marrow cells and endothelial cells lining the inside surface of blood vessels. Its primary function is platelet adhesion, binding to Factor VIII, collagen and platelets, to coagulate blood at the site of wounding. The enzyme VWFCP, or vWF-cleaving protease, facilitates clotting by cutting the protein into subunits, increasing its binding capacity.
Deficiency or dysfunction of the protein increases the tendency of wounds to bleed, or to bleed more. �Over 300 gene mutations have been identified and classified into three types. �Type 1 von Willebrand Factor disease is characterized by reduced amounts in the bloodstream, Type 2 by reduced binding ability and Type 3 by a nonfunctional protein.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Gene ID #:
7450
Immunogen:
A recombinant human protein fragment was used as the immunogen for this von Willebrand Factor antibody.
Limitation:
This von Willebrand Factor antibody is available for research use only.
Localization:
Cytoplasmic
Purity:
Protein G purified
Species Reactivity :
Human