BMPR1B Antibody

Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 472-502 from the human protein was used as the immunogen for this BMPR1B antibody.

This BMPR1B antibody is available for research use only.

Purified

Human

Mouse, Chicken

O00238