Claudin 1 Antibody

Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Titration of the Claudin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 40-82 from the human protein (loop 1) was used as the immunogen for this Claudin 1 antibody.

This Claudin 1 antibody is available for research use only.

Purified

Human

O95832