LRP6 Antibody

Contact us
NSJ Bioreagents
Product Code: NSJ-F49462
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F49462-0.08ML0.08 ml£260.00
Quantity:
NSJ-F49462-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Aliquot the LRP6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

1 / 2
Western blot analysis of LRP6 antibody and 293 cell lysate either nontransfected or transiently transfected with the LRP6 gene.~
2 / 2
IHC analysis of FFPE human breast carcinoma tissue stained with LRP6 antibody
❮❯

Western blot analysis of LRP6 antibody and 293 cell lysate either nontransfected or transiently transfected with the LRP6 gene.~
IHC analysis of FFPE human breast carcinoma tissue stained with LRP6 antibody

Documents

Further Information

Application Details :
Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
Application Note:
Titration of the LRP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.
Limitation:
This LRP6 antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human
Uniprot #:
O75581