PKC beta Antibody

Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Titration of the PKC beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 303-334 from the human protein was used as the immunogen for this PKC beta antibody.

This PKC beta antibody is available for research use only.

Purified

Human

P05771