SIGLEC7 Antibody

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NSJ Bioreagents
Product Code: NSJ-F40104
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F40104-0.08ML0.08 ml£260.00
Quantity:
NSJ-F40104-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Aliquot the SIGLEC7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

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SIGLEC7 antibody used in western blot to detect Dsiglec/SIGLEC7 in Jurkat cell lysate~
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IHC analysis of FFPE human hepatocarcinoma stained with the SIGLEC7 antibody
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SIGLEC7 antibody used in western blot to detect Dsiglec/SIGLEC7 in Jurkat cell lysate~
IHC analysis of FFPE human hepatocarcinoma stained with the SIGLEC7 antibody

Documents

Further Information

Application Details :
Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the SIGLEC7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
SIGLECs are cell surface proteins of the Ig superfamily. SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). [UniProt]
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 407-438 from the human protein was used as the immunogen for this SIGLEC7 antibody.
Limitation:
This SIGLEC7 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
Q9Y286