TLR3 Antibody

Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Titration of the TLR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

This TLR3 antibody was produced from rabbits immunized with TLR3 recombinant protein.

This TLR3 antibody is available for research use only.

Antigen affinity

Human

O15455