SIRT5 Antibody
| Code | Size | Price |
|---|
| NSJ-F49521-0.08ML | 0.08 ml | £260.00 |
Quantity:
| NSJ-F49521-0.4ML | 0.4 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Aliquot the SIRT5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
Application Note:
Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.
Limitation:
This SIRT5 antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human
Uniprot #:
Q9NXA8