FOXP3 Antibody

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NSJ Bioreagents
Product Code: NSJ-F48211
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F48211-0.08ML0.08 ml£260.00
Quantity:
NSJ-F48211-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store at 4oC for up to one month. For long term, aliquot the FOXP3 antibody and store frozen at -20oC or colder.

Images

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FOXP3 antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).
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IHC analysis of FFPE human lymph tissue stained with FOXP3 antibody
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Western blot analysis of FOXP3 antibody and (1) 293, (2) Jurkat and (3) mouse liver lysate.
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FOXP3 antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).
IHC analysis of FFPE human lymph tissue stained with FOXP3 antibody
Western blot analysis of FOXP3 antibody and (1) 293, (2) Jurkat and (3) mouse liver lysate.

Documents

Further Information

Application Details :
Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50
Application Note:
The stated application concentrations are suggested starting points. Titration of the FOXP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Forkhead box P3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). [UniProt]
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 283-311 from the human protein was used as the immunogen for this FOXP3 antibody.
Limitation:
This FOXP3 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse
Species Reactivity (Predicted):
Primate
Uniprot #:
Q9BZS1