ERK4 Antibody

Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Titration of the ERK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The CMGC group consists of 60 kinases including the cyclin-dependent kinase (CDK) and close relatives family, the MAP kinase (ERK) family, the glycogen synthase kinase 3 (GSK3) family, and the Cdc2-like kinase (CLK) family.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 527-557 from the human protein was used as the immunogen for this ERK4 antibody.

This ERK4 antibody is available for research use only.

Purified

Human, Mouse

P31152