SUV39H2 Antibody (KMT1B)

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NSJ Bioreagents
Product Code: NSJ-F42487
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F42487-0.08ML0.08 ml£260.00
Quantity:
NSJ-F42487-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Aliquot the SUV39H2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

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Western blot analysis of lysate from 1) HepG2 and 2) HUVEC cell line using SUV39H2 antibody at 1:1000.
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Western blot testing of SUV39H2 antibody and mouse kidney tissue lysate
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IHC analysis of FFPE human breast carcinoma tissue stained with the SUV39H2 antibody
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Western blot analysis of lysate from 1) HepG2 and 2) HUVEC cell line using SUV39H2 antibody at 1:1000.
Western blot testing of SUV39H2 antibody and mouse kidney tissue lysate
IHC analysis of FFPE human breast carcinoma tissue stained with the SUV39H2 antibody

Documents

Further Information

Application Details :
Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
Application Note:
Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.
Limitation:
This SUV39H2 antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human, Mouse
Uniprot #:
Q9H5I1