PROX1 Antibody
| Code | Size | Price |
|---|
| NSJ-F47894-0.08ML | 0.08 ml | £260.00 |
Quantity:
| NSJ-F47894-0.4ML | 0.4 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Aliquot the PROX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
Western blot: 1:500,Immunofluorescence: 1:10-1:50
Application Note:
Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 492-522 from the human protein was used as the immunogen for this PROX1 antibody.
Limitation:
This PROX1 antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human, Rat
Species Reactivity (Predicted):
Mouse
Uniprot #:
Q92786