METTL14 Antibody (N-Terminal Region)
| Code | Size | Price |
|---|
| NSJ-F54217-0.05ML | 0.05 ml | £260.00 |
Quantity:
| NSJ-F54217-0.2ML | 0.2 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Aliquot the METTL14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
Western Blot: 1:2000
Application Note:
The stated application concentrations are suggested starting points. Titration of the METTL14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
N6-adenosine-methyltransferase subunit METTL14 is an N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 2-36 from the N-terminal region of the human protein was used as the immunogen for the METTL14 antibody.
Limitation:
This METTL14 antibody is available for research use only.
Purity:
Peptide affinity purified
Species Reactivity :
Human, Mouse
Species Reactivity (Predicted):
Bovine
Uniprot #:
Q9HCE5