Transthyretin Antibody / TTR / Prealbumin

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NSJ Bioreagents
Product Code: NSJ-F54873
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F54873-0.08ML0.08 ml£260.00
Quantity:
NSJ-F54873-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Aliquot the Transthyretin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

1 / 4
IHC testing of FFPE human liver tissue with Transthyretin antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
2 / 4
Western blot testing of human 1) placenta and 2) plasma lysate with Transthyretin antibody. Predicted molecular weight ~16 kDa.
3 / 4
Immunofluorescent staining of human pancreas and kidney tissue with Transthyretin antibody (green) and DAPI nuclear stain (blue).
4 / 4
Flow cytometry testing of fixed and permeabilized human HepG2 cells with Transthyretin antibody; Blue=isotype control, Green= Transthyretin antibody.
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IHC testing of FFPE human liver tissue with Transthyretin antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Western blot testing of human 1) placenta and 2) plasma lysate with Transthyretin antibody. Predicted molecular weight ~16 kDa.
Immunofluorescent staining of human pancreas and kidney tissue with Transthyretin antibody (green) and DAPI nuclear stain (blue).
Flow cytometry testing of fixed and permeabilized human HepG2 cells with Transthyretin antibody; Blue=isotype control, Green= Transthyretin antibody.

Documents

Further Information

Application Details :
Immunofluorescence: 1:25, Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE): 1:25, Flow cytometry: 1:25 (1x10e6 cells)
Application Note:
The stated application concentrations are suggested starting points. Titration of the Transthyretin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 71-98 from the human protein was used as the immunogen for the Transthyretin antibody.
Limitation:
This Transthyretin antibody is available for research use only.
Localization:
Cytoplasmic
Purity:
Antigen affinity purified
Species Reactivity :
Human
Uniprot #:
P02766