DYRK2 Antibody

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NSJ Bioreagents
Product Code: NSJ-F54682
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F54682-0.08ML0.08 ml£260.00
Quantity:
NSJ-F54682-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Aliquot the DYRK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

1 / 4
Western blot testing of 1) human HeLa, 2) human HepG2, 3) human SK-OV-3 and 4) mouse C2C12 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
2 / 4
Western blot testing of human K562 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
3 / 4
Western blot testing of 1) human CCRF-CEM, 2) human HepG2, 3) human K562 and 4) mouse Ba/F3 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
4 / 4
IHC testing of FFPE human testis tissue with DYRK2 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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Western blot testing of 1) human HeLa, 2) human HepG2, 3) human SK-OV-3 and 4) mouse C2C12 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
Western blot testing of human K562 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
Western blot testing of 1) human CCRF-CEM, 2) human HepG2, 3) human K562 and 4) mouse Ba/F3 cell lysate with DYRK2 antibody. Predicted molecular weight ~67 kDa.
IHC testing of FFPE human testis tissue with DYRK2 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

Documents

Further Information

Application Details :
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE): 1:25
Application Note:
The stated application concentrations are suggested starting points. Titration of the DYRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 521-549 from the mouse protein was used as the immunogen for the DYRK2 antibody.
Limitation:
This DYRK2 antibody is available for research use only.
Localization:
Cytoplasmic, nuclear
Purity:
Antigen affinity purified
Species Reactivity :
Human, Mouse
Uniprot #:
Q5U4C9