ASXL1 Antibody

Western blot: 1:500-1:2000, Immunohistochemistry (FFPE): 1:25, Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25

The stated application concentrations are suggested starting points. Titration of the Additional sex combs-like protein 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 521-549 from the human protein was used as the immunogen for the Additional sex combs-like protein 1 antibody.

This Additional sex combs-like protein 1 antibody is available for research use only.

Nuclear

Antigen affinity purified

Human, Mouse

Q8IXJ9