NSJ Bioreagents

GFRAL Antibody

Product Code:
 
NSJ-F54320
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Aliquot the GFRAL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
1 / 5
Western blot testing of human brain lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
2 / 5
Western blot testing of human MDA-MB-435 cell lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
3 / 5
Western blot testing of human MDA-MB-453 cell lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
4 / 5
IHC testing of FFPE human brain tissue with GFRAL antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
5 / 5
Flow cytometry testing human MDA-MB-435 cells with GFRAL antibody; Blue=isotype control, Green= GFRAL antibody.
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Western blot testing of human brain lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
Western blot testing of human MDA-MB-435 cell lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
Western blot testing of human MDA-MB-453 cell lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.
IHC testing of FFPE human brain tissue with GFRAL antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Flow cytometry testing human MDA-MB-435 cells with GFRAL antibody; Blue=isotype control, Green= GFRAL antibody.

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CodeSizePrice
NSJ-F54320-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54320-0.2ML0.2 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:25,Flow cytometry: 1:25 (1x10e6 cells)
Application Note:
The stated application concentrations are suggested starting points. Titration of the GFRAL antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt]
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 366-394 from the human protein was used as the immunogen for the GFRAL antibody.
Limitation:
This GFRAL antibody is available for research use only.
Purity:
Antigen affinity purified
Species Reactivity :
Human
Uniprot #:
Q6UXV0