CYLD Antibody
| Code | Size | Price |
|---|
| NSJ-N1164-25UG | 25 ug | £254.00 |
Quantity:
| NSJ-N1164-100UG | 100 ug | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Aliquot the CYLD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
Western blot: 2-5ug/ml
Application Note:
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
Buffer:
1X PBS, pH 7.4
Description:
CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
Format :
Purified
Formulation :
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Gene ID #:
1540
Immunogen:
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
Limitation:
This CYLD antibody is available for research use only.
Purity:
Protein A affinity chromatography
Species Reactivity :
Human, Mouse