DC-SIGN Antibody
| Code | Size | Price |
|---|
| NSJ-N1090-25UG | 25 ug | £254.00 |
Quantity:
| NSJ-N1090-100UG | 100 ug | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Aliquot the DC-SIGN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
Western blot: 2-5ug/ml
Application Note:
Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.
Buffer:
1X PBS, pH 7.4
Description:
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
Format :
Purified
Formulation :
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Gene ID #:
30835
Immunogen:
A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
Limitation:
This DC-SIGN antibody is available for research use only.
Purity:
Protein A purified antibody
Species Reactivity :
Human, Mouse