CLEC4E Antibody
| Code | Size | Price |
|---|
| NSJ-N1058-25UG | 25 ug | £254.00 |
Quantity:
| NSJ-N1058-100UG | 100 ug | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Aliquot the CLEC4E antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details :
Western blot: 2-5ug/ml
Application Note:
Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.
Buffer:
1X PBS, pH 7.4
Description:
CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.
Format :
Purified
Formulation :
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Gene ID #:
26253
Immunogen:
A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.
Limitation:
This CLEC4E antibody is available for research use only.
Purity:
Protein A affinity chromatography
Species Reactivity :
Human, Mouse, Rat