TRPV4 Antibody / Transient receptor potential cation channel subfamily V member 4

Western blot: 0.5-1ug/ml,Direct ELISA: 0.1-0.5ug/ml

Optimal dilution of the TRPV4 antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4), also known as TRP12, OTRPC4 or VROAC, is a protein that in humans is encoded by the TRPV4 gene. This gene encodes TRPV4, a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. By genomic sequence analysis, Liedtke et al.(2000) mapped the TRPV4 gene to chromosome 12q24.1. They mapped the mouse Trpv4 gene to distal chromosome 5 by radiation hybrid analysis. Wissenbach et al.(2000) found that hypoosmotic conditions rapidly activated TRP12, while hyperosmotic conditions inhibited the activity. Strotmann et al.(2000) showed that OTRPC4 was responsive to changes in extracellular osmolarity in the physiologically relevant range and was expressed in tissues exposed to changing osmotic environments.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Recombinant human protein (amino acids N66-L871) was used as the immunogen for the TRPV4 antibody.

This TRPV4 antibody is available for research use only.

Affinity purified

Human, Mouse, Rat

Q9HBA0