anti-HSP70 (human) Rabbit Monoclonal (RM432)
| Code | Size | Price |
|---|
| REV-31-1320-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM432
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Long Term: -20°C
Documents
Further Information
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A recombinant human HSP70 protein.
Long Description:
Recombinant Antibody. This antibody RM431 reacts to human HSP70. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. HSP70 is a molecular chaperone expressed constitutively under normal conditions to maintain protein homeostasis and is induced upon environmental stress. It functions by acting as molecular chaperones, facilitating protein refolding and preventing protein aggregation. It has been reported that extracellular HSP70 also exhibits immunomodulatory effects on innate and acquired immunity. HSP70 is membrane associated in lysosomes, mitochondria,and the outer surface of cancer cells. It plays a role in vesicle formation and protein trafficking. HSP70 expression in colorectal carcinoma and breast carcinoma has been significantly correlated with low differentiation and poor prognosis, whereas in renal cell carcinoma it has been reported to be associated with good prognosis. Expression of HSPs on the surface of tumor cells, instead of their normal intracellular location, suggests they play a role in inducing an immune response against cancer.
Package Type:
Vial
Product Description:
HSP70 is a molecular chaperone expressed constitutively under normal conditions to maintain protein homeostasis and is induced upon environmental stress. It functions by acting as molecular chaperones, facilitating protein refolding and preventing protein aggregation. It has been reported that extracellular HSP70 also exhibits immunomodulatory effects on innate and acquired immunity. HSP70 is membrane associated in lysosomes, mitochondria,and the outer surface of cancer cells. It plays a role in vesicle formation and protein trafficking. HSP70 expression in colorectal carcinoma and breast carcinoma has been significantly correlated with low differentiation and poor prognosis, whereas in renal cell carcinoma it has been reported to be associated with good prognosis. Expression of HSPs on the surface of tumor cells, instead of their normal intracellular location, suggests they play a role in inducing an immune response against cancer.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
RM431 reacts to human HSP70.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.