anti-RNASEH2B (human) Rabbit Monoclonal (RM433)

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RevMab Biosciences
Product Code: REV-31-1321-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1321-00-R100100 ul£455.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM433
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Long Term: -20°C

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Further Information

Alternate Names/Synonyms:
RNase H2 Subunit B; Ribonuclease H2 Subunit B; Aicardi-Goutieres Syndrome 2 Protein; AGS2; Deleted in Lymphocytic Leukemia 8
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the C-terminus of human RNASEH2B.
Long Description:
Recombinant Antibody. This antibody RM433 reacts to human RNASEH2B. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.
NCBI, Uniprot Number:
Q5TBB1
Package Type:
Vial
Product Description:
RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
RM433 reacts to human RNASEH2B.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.