Dansyl fluoride
| Code | Size | Price |
|---|
| CDX-D0241-M250 | 250 mg | £72.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term Storage: +4?C. Long Term Storage: +4?C
Documents
Further Information
Alternate Names/Synonyms:
5-(Dimethylamino)-1-naphthalenesulfonyl fluoride; DNSF
Appearance:
Yellow powder.
CAS:
34523-28-9
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS05
Handling Advice:
Protect from light and moisture.
Hazards:
H314
InChi:
InChI=1S/C12H12FNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChiKey:
JMHHECQPPFEVMU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 34523-28-9. Formula: C12H12FNO2S. Molecular Weight: 253.3. Dansyl fluoride is a fluorogenic reagent used as a specific fluorescent probe for serine proteases and is a serine-type protease inhibitor. It is an active site directed fluorescent inhibitor of guanidinobenzoatase (GB), which binds to both the colonic isoenzymic forms of the GB. The GB on cell surfaces after binding dansyl fluoride makes the cells fluoresce blue. It has been used for the location of tumour cells in frozen sections of human lung squamous cell carcinoma and colonic carcinoma tissues. It is used as a precursor for the synthesis of other derivatives like dansyl amide. Spectral data: lambdaex 360nm; lambdaem 580nm (methanol).
MDL:
MFCD00042702
Molecular Formula:
C12H12FNO2S
Molecular Weight:
253.3
Package Type:
Vial
PG:
II
Precautions:
P280-P305 + P351 + P338-P310
Product Description:
Dansyl fluoride is a fluorogenic reagent used as a specific fluorescent probe for serine proteases and is a serine-type protease inhibitor. It is an active site directed fluorescent inhibitor of guanidinobenzoatase (GB), which binds to both the colonic isoenzymic forms of the GB. The GB on cell surfaces after binding dansyl fluoride makes the cells fluoresce blue. It has been used for the location of tumour cells in frozen sections of human lung squamous cell carcinoma and colonic carcinoma tissues. It is used as a precursor for the synthesis of other derivatives like dansyl amide. Spectral data: lambdaex 360nm; lambdaem 580nm (methanol).
Purity:
>98% (HPLC)
Signal Word:
Danger
SMILES:
CN(C)C1=C(C=CC=C2S(=O)(F)=O)C2=CC=C1
Solubility Chemicals:
Soluble in chloroform or methanol.
Transportation:
Excepted Quantity
UN Nummer:
3261
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) W.L Vaz & G. Schoellmann; Biochim. Biophys. Acta 439, 194 (1976) | (2) J. Stackhouse & F.H. Westheimer; J. Org. Chem. 46, 1891 (1981) | (3) G. Schoellmann, et al.; Biochim. Biophys. Acta 704, 403 (1982) | (4) R.F. Chen & C.H. Scott; Anal. Lett. 18, 393 (1985) | (5) M. Anees & E.W. Benbow; J. Enzyme Inhib. 10, 195 (1996) | (6) R. Zhou, et al.; PNAS 95, 4959 (1998)