anti-GLUT2 (human) pAb (IN117)

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AdipoGen Life Sciences
Product Code: AG-25B-0041
Product Group: Primary Antibodies
CodeSizePrice
AG-25B-0041-C05050 ug£200.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Short Term Storage: +4?C. Long Term Storage: -20?C

Images

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Figure 1: Detection of endogenous human GLUT2 in human liver membranes by immunoblotting using anti-GLUT2 (human), pAb (IN117) (Prod. No. AG-25B-0041).
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Figure 1: Detection of endogenous human GLUT2 in human liver membranes by immunoblotting using anti-GLUT2 (human), pAb (IN117) (Prod. No. AG-25B-0041).

Documents

Further Information

Alternate Names/Synonyms:
Solute Carrier Family 2, Facilitated Glucose Transporter Member 2; SLC2A2; Glucose Transporter Type 2, Liver
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% Proclin 300.
Handling Advice:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Immunogen:
A synthetic peptide corresponding to 12 aa located near the C-terminus of human GLUT2.
Long Description:
Polyclonal Antibody. Recognizes human GLUT2. Applications: IHC, IP, WB. Source: Rabbit. GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l). GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.
NCBI, Uniprot Number:
P11168
Package Type:
Plastic Vial
Product Description:
GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l). GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.
Purity:
>95% (SDS-PAGE)
Source / Host:
Rabbit
Specificity:
Recognizes human GLUT2.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human beta cell regeneration: C. Ackeifi, et al.; Sci. Transl. Med. 12, eaaw9996 (2020)