Biotin Sulfone
| Code | Size | Price |
|---|
| CDX-B0606-M100 | 100 mg | £89.00 |
Quantity:
| CDX-B0606-M250 | 250 mg | £169.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term Storage: -20?C. Long Term Storage: -20?C
Documents
Further Information
Alternate Names/Synonyms:
Biotin 5,5-Dioxide; (3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid, 5,5-dioxide
Appearance:
Colorless needles.
CAS:
40720-05-6
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C10H16N2O5S/c13-8(14)4-2-1-3-7-9-6(5-18(7,16)17)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChiKey:
QPFQYMONYBAUCY-ZKWXMUAHSA-N
Long Description:
Chemical. CAS: 40720-05-6. Formula: C10H16N2O5S. Molecular Weight: 276.31. Biotin sulfone is an oxidized form of biotin and is as efficient as biotin in streptavidin binding and it binds to avidin with a binding ratio of 0.332 compared with biotin. Biotinylated synthetic oligosaccharides are an attractive tool, as streptavidin coated plates and beads are commercially available and widely use in serological assays. As biotin is chemically reactive, and not compatible with carbohydrate protecting group manipulation, the use of biotin sulfone tagged oligomannosides (BSTO) for antigen immobilization in candidiasis or allergy diagnosis has been used. The use of biotin sulfone also offers a convenient solution for both oligosaccharide synthesis and immobilization on microspheres and surface plasmon resonance sensors.
MDL:
MFCD08444234
Molecular Formula:
C10H16N2O5S
Molecular Weight:
276.31
Package Type:
Vial
Product Description:
Biotin sulfone is an oxidized form of biotin and is as efficient as biotin in streptavidin binding and it binds to avidin with a binding ratio of 0.332 compared with biotin. Biotinylated synthetic oligosaccharides are an attractive tool, as streptavidin coated plates and beads are commercially available and widely use in serological assays. As biotin is chemically reactive, and not compatible with carbohydrate protecting group manipulation, the use of biotin sulfone tagged oligomannosides (BSTO) for antigen immobilization in candidiasis or allergy diagnosis has been used. The use of biotin sulfone also offers a convenient solution for both oligosaccharide synthesis and immobilization on microspheres and surface plasmon resonance sensors.
Purity:
>98% (NMR)
SMILES:
O=C1N[C@@H]2[C@@H]([C@H](CCCCC(O)=O)S(C2)(=O)=O)N1
Solubility Chemicals:
Slightly soluble in aqueous base or DMSO (<1mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20?C.
References
(1) J. Zempleni & D.M. Mock; J. Nutr. 129, 494S (1999) | (2) M. Collot, et al.; J. Med. Chem. 51, 6201 (2008) | (3) G. Despras, et al.; Bioorg. Med. Chem. 20, 1817 (2012)