4-Methylumbelliferyl palmitate

4-MUP; 4-MU Palmitate; 4-Methyl-2-oxo-2H-chromen-7-yl palmitate; Palmitic acid 4-methylumbelliferyl ester

White to off-white crystalline powder.

17695-48-6

32160000

solid

Protect from light and moisture.

InChI=1S/C26H38O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-25(27)29-22-17-18-23-21(2)19-26(28)30-24(23)20-22/h17-20H,3-16H2,1-2H3

QKQVFFACWLFRRX-UHFFFAOYSA-N

Chemical. CAS: 17695-48-6. Formula: C26H38O4. Molecular Weight: 414.59. 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL). 4-MUP is cleaved by LAL (or by other acid lipases) to release the fluorescent moiety 4-MU. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP. Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase. Spectral data: 4-MU fluorescence is pH-dependent. lambdaex 320nm (pH 1.97-6.72) and 360nm (pH 7.12-10.3); lambdaem 445-455nM (increasing as pH decreases).

MFCD00037612

C26H38O4

414.59

Vial

4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL). 4-MUP is cleaved by LAL (or by other acid lipases) to release the fluorescent moiety 4-MU. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP. Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase. Spectral data: 4-MU fluorescence is pH-dependent. lambdaex 320nm (pH 1.97-6.72) and 360nm (pH 7.12-10.3); lambdaem 445-455nM (increasing as pH decreases).

>95% (NMR)

O=C1OC2=CC(OC(CCCCCCCCCCCCCCC)=O)=CC=C2C(C)=C1

Soluble in DCM (10mg/ml), chloroform (20mg/ml) or DMF (10mg/m).

Non-hazardous

Fluorescent Reagents

41105331

Stable for at least 2 years after receipt when stored at -20?C.