MNDA (IN) Antibody
Code | Size | Price |
---|
PSI-9647-0.02mg | 0.02mg | £150.00 |
Quantity:
PSI-9647-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
MNDA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
MNDA
Application Note:
WB: 1 μg/mL; IHC: 1 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
MNDA Antibody: MNDA controls the expression of MCL-1 and BCL02 in chronic lymphocytic leukemia cells. MNDA is also a useful marker in the recognition and differential diagnosis of marginal zone lymphomas. MNDA has a role in regulating programmed cell death in myeloid progenitor cells, and its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death.
Background References:
- Bottari et al. Exp Hematol. 2020; 88:68-82
- Wang et al. Am. J. Clin. Pathol. 2019; 151(3):337-343
- Kanellis et al. Lukemia 2019; 23(10):1847-1857
- Briggs et al. Cancer Res. 2006; 66(9): 4645-4651
Buffer:
MNDA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
Homology:
Predicted species reactivity based on immunogen sequence: Gorilla (93%), chimpanzee (100%), Monkey (87%)
Immunogen:
Anti-MNDA antibody (9647) was raised against a peptide corresponding to 15 amino acids near the center of human MNDA. The immunogen is located within 110-160 amino acids of MNDA.
ISOFORMS:
Human MNDA has one isoform (407aa, 45.8kD). Mouse MNDA has 2 isoforms, isoform 1 (425aa, 47kD) and isoform 2 (423aa, 46.8kD). Rat MNDA has one isoform (438aa, 49.7kD). 9647 can detect MNDA in human, but not in mouse and rat.
NCBI Gene ID #:
4332
NCBI Official Name:
myeloid cell nuclear differentiation antigen
NCBI Official Symbol:
MNDA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 46kD
Observed: 46 kD
Observed: 46 kD
Protein Accession #:
P41218.1
Protein GI Number:
730038
Purification:
MNDA Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
P41218.1
User NOte:
Optimal dilutions for each application to be determined by the researcher.