AIFM2 (IN) Peptide
| Code | Size | Price |
|---|
| PSI-9655P-0.05mg | 0.05mg | £166.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Blocking
Storage:
Store AIFM2 (IN) Peptide at -20˚C, stable for one year.
Documents
Further Information
Additional Names:
AIMF2
Application Note:
AIFM2 (IN) Peptideis used for blocking the activity of theAIFM2 (IN) Antibody
Background:
AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis
Background References:
- Dai et al. Biochem Biophys Res Commun. 2020; 523(4):966-971
- Bersuker et al. Nature 2019; 575(7784):688-692
- Doll et al. Nature 2019; 575(7784):693-698
- Chen et al. J Mol Neurosci 2019; 68(2): 304-310
- Gong et al. J Biol Chem 2007; 282(41):30331-30340
Buffer:
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Concentration:
200 ug/mL
NCBI Gene ID #:
84883
NCBI Official Name:
apoptosis inducing factor mitochondria associated
NCBI Official Symbol:
AIMF2
NCBI Organism:
Homo sapiens
Peptide aa Location:
14 amino acids near the center of AIFM2 (IN).
Physical State:
Liquid
Protein Accession #:
Q9BRQ8
Protein GI Number:
74752283
Swissprot #:
Q9BRQ8
User Note:
Optimal dilutions for each application to be determined by the researcher.