ProSci

IRGB10 (CT) Peptide

Product Code:
 
PSI-9515P
Product Group:
 
Peptides
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Blocking
Storage:
 
Store IRGB10 (CT) Peptide at -20˚C, stable for one year.
 

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CodeSizePrice
PSI-9515P-0.05mg0.05mg£166.00
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Further Information

Additional Names:
IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723
Application Note:
IRGB10 (CT) Peptideis used for blocking the activity of theIRGB10 (CT) Antibody
Background:
IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.
Background References:
  • Man et al. Cell 2016; 167(2):382-396.e17
  • Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103(38):14092-14097
  • Miyairi I et al. J Immunol 2007; 179(3):1814-1824
  • Coers J et al. J Immunol 2008; 180(9):6237-6245
Buffer:
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Concentration:
200 ug/mL
NCBI Gene ID #:
631323
NCBI Official Name:
predicted gene 12250
NCBI Official Symbol:
IRGB10
NCBI Organism:
Mus musculus
Peptide aa Location:
13 amino acids near the carboxy terminus of IRGB10 (CT).
Physical State:
Liquid
Protein Accession #:
AGY29631
Protein GI Number:
551032829
Swissprot #:
AGY29631
User Note:
Optimal dilutions for each application to be determined by the researcher.

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