FKBP12 Antibody / FKBP1A

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NSJ Bioreagents
Product Code: NSJ-F54946
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-F54946-0.08ML0.08 ml£260.00
Quantity:
NSJ-F54946-0.4ML0.4 ml£502.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Aliquot the FKBP1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Images

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IHC testing of FFPE human hepatocellular carcinoma tissue with FKBP1A antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
2 / 4
Western blot testing of human Jurkat cell lysate with FKBP1A antibody. Predicted molecular weight ~12 kDa.
3 / 4
Western blot testing of 1) non-transfected and 2) transfected 293 cell lysate with FKBP1A antibody.
4 / 4
Flow cytometry testing of human MDA-MB-231 cells with FKBP1A antibody; Blue=isotype control, Green= FKBP1A antibody.
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IHC testing of FFPE human hepatocellular carcinoma tissue with FKBP1A antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Western blot testing of human Jurkat cell lysate with FKBP1A antibody. Predicted molecular weight ~12 kDa.
Western blot testing of 1) non-transfected and 2) transfected 293 cell lysate with FKBP1A antibody.
Flow cytometry testing of human MDA-MB-231 cells with FKBP1A antibody; Blue=isotype control, Green= FKBP1A antibody.

Documents

Further Information

Application Details :
Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:500-1:1000, Immunohistochemistry (FFPE): 1:50-1:100
Description:
FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 55-83 from the human protein was used as the immunogen for the FKBP1A antibody.
Limitation:
This FKBP1A antibody is available for research use only.
Localization:
Cytoplasmic
Purity:
Purified
Species Reactivity :
Human
Uniprot #:
P62942