ACVR1B Antibody / Activin receptor type-1B / ALK4

Western blot: 1:500-1:1000, Flow cytometry: 1:25 (1x10e6 cells)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 39-68 from the human protein was used as the immunogen for the Activin receptor type-1B antibody.

This Activin receptor type-1B antibody is available for research use only.

Antigen affinity purified

Human, Mouse, Rat

P36896