Luteinizing Hormone beta Antibody

Immunohistochemistry (FFPE): 1-2ug/ml

Optimal dilution of the recombinant Luteinizing Hormone beta antibody should be determined by the researcher.

LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Recombinant full-length human LHB protein was used as the immunogen for the recombinant Luteinizing Hormone beta antibody.

This recombinant Luteinizing Hormone beta antibody is available for research use only.

Cytoplasm, Secreted

Protein A/G affinity

Human

P01229